Mfg: Bristol-Myers Squibb; Otsuka America Pharmaceutical
Indication(s): Treatment of schizophrenia
Administration: Recommended starting dose and target dose 10 mg/day or 15 mg/day administered once daily. Effective in a dosage range of 10 to 30 mg/day.
Pharmacology: An antipsychotic drug. It is theorized that the efficacy of aripiprazole is mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors.
WebRx Editorial Notes: No dosage adjustment required on basis of age, gender, race, smoking status, liver function, or kidney function. The long term effectiveness greater than 52 weeks in treatment of schizophrenia has not been established.
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